NRE Step 1: Pharmacology Made Simple – Pass with Precision

Here’s the information about medicines, explained simply for a 6th-grade reading level:

Understanding Medicines

  • Agonist medicines are like keys that fit into a lock and make something happen in your body.
  • Antagonist medicines are like keys that fit into the same lock but just block it, so nothing happens.

Blood Pressure and Heart Medicines

  • Some medicines for high blood pressure, like those ending in “-pril,” can cause a dry cough and swelling.
  • Spironolactone can cause breast growth in men and too much potassium in the body.
  • Hydralazine and Alpha methyl dopa are used for high blood pressure, especially for pregnant women.
  • Labetalol and Carvedilol help with blood pressure by acting on certain body signals.
  • Metoprolol is used for high cholesterol.
  • Digoxin makes your heart beat stronger by stopping a pump in your body.

Cholesterol Medicines

  • Statins stop your body from making too much cholesterol. They can sometimes hurt your liver or muscles.
  • Fibrates, when used with statins, can increase the chance of getting gallstones.
  • Niacin (also called Vitamin B3) is another medicine for cholesterol.

Heartbeat Rhythm Medicines

  • Sodium channel blockers like Quinidine, Procainamide, and Disopyramide help with heart rhythm.
    • Quinidine can cause ringing in the ears, dizziness, and headaches.
  • Potassium channel blockers include Amiodarone.
  • Calcium channel blockers include Diltiazem and Verapamil.

Thyroid Medicines

  • PTU is used for thyroid problems, especially in the first three months of pregnancy.
  • Methimazole is used in the second and third trimesters of pregnancy.
  • Levothyroxine is a common medicine for thyroid conditions.

Diabetes Medicines

  • Insulin can cause low blood sugar.
  • Metformin is used for type 2 diabetes, especially for people who are overweight. It’s not for people with kidney problems.
  • Sulfonylureas like Glyburide and Tolbutamide can cause low blood sugar and weight gain.
  • Pioglitazone can increase the risk of bone fractures.
  • SGLT2 inhibitors like Empagliflozin and Dapagliflozin help your body get rid of sugar through your urine.

Stomach and Digestion Medicines

  • PPIs (Proton Pump Inhibitors) stop too much stomach acid.
  • H2 blockers like Cimetidine also reduce stomach acid, but Cimetidine can cause breast growth in men.
  • Misoprostol protects your stomach from certain other medicines.
  • Antacids:
    • Aluminum Hydroxide can cause constipation.
    • Aluminum Magnesium Hydroxide can cause diarrhea.
  • Anti-vomit medicines:
    • Ondansetron helps stop throwing up, especially from chemotherapy.
    • Metoclopramide can cause side effects like Parkinson’s disease and is used for stomach problems in diabetics.
    • Aprepitant is a newer medicine to stop throwing up.
  • Domperidone is another medicine for stomach issues.

Laxatives and Anti-Diarrhea Medicines

  • Lactulose is used for constipation and a brain problem called hepatic encephalopathy.
  • Metronidazole and Loperamide are medicines for diarrhea.

Water Pills (Diuretics)

  • Loop diuretics help your body get rid of extra water, especially when there’s fluid in the lungs.
  • Thiazide diuretics are used for mild high blood pressure.
  • Potassium-sparing diuretics like Spironolactone can make your body too acidic.
  • Acetazolamide makes your pee more acidic and can make your blood more acidic.
  • Osmotic diuretics pull extra fluid out of your body’s cells.

Bladder Control Medicines

  • Muscarinic antagonists like Oxybutynin help with needing to pee often or suddenly.
  • Muscarinic agonists like Bethanechol help empty the bladder if you have trouble peeing.
  • Mirabegron helps your bladder hold more pee.
  • Tamsulosin helps relax muscles in the urinary area, used for prostate problems in men.

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